The Effect of Citral on Aquaporin 5 and Trpv4 Expressions and Uterine Contraction in Rat—An Alternative Mechanism

Aquaporins (AQPs) are expressed in the uterus, playing a physiological role during pregnancy. An osmotic pathway—through AQP5—may modify transient potential vanilloid 4 (TRPV4) function and uterine contraction. Our aim was to determine of TRPV4 antagonist citral regulation pregnant In vitro contractions were evoked by KCl response modified with citral. The expressions AQP5 measured RT-PCR Western blot techniques. lengths gestational periods determined normal LPS-induced preterm births after treatment, vivo. Citral significantly decreased contraction on day 22 expression increased incubation; however, did not show significant changes. After pretreatment, period extended both births. results suppose that downregulation may initiate hypertonic stress, activating last period. putative cooperation between open novel target treat or prevent birth.